Members of the Unite union at Dundee University have backed strike action as the institution tackles a financial crisis that has put up to 700 jobs at risk.
The university faces a £35m deficit and previously announced that hundreds of positions would be cut.
It is understood that union members voted 70 to 31 in favour of strike action, with a turnout of almost 61%.
Unite said it would support its members "every step of the way in defence of their jobs," while the university said it would wait to hear from the union about any potential strike action.
The union said a rally and march involving trade unionists, community activists, students and workers would take place in Dundee City Centre on Tuesday.
Katrina Currie, Unite industrial officer, said: "We need every tool in defence of jobs and livelihoods which is why this industrial action mandate is vital."
A Dundee University spokesman said: "We have had notification from Unite of the ballot result and we will wait to hear more from the union on any action.
"We will continue to engage with all of our campus unions as we work towards a financial recovery."
